Hiya!
My information may be dated, but it isn't 'lacking'

I have not loaded for the .45Colt in a number of years now. What I saw then may have changed; I'll welcome updated information.
Sectioning brass (and game bullets) has always been a hobby of mine. .45 Colt brass was thinner than the magnum. If you have sectioned any recent brass I'd appreciate an update. Brass has been getting thicker across the board for a long time. Loads that were safe 20 years ago no longer are with new components.
In keeping with Josh's original post, I was referring to S&W Hand Ejectors and similar DA revolvers suitable for daily carry. The chamber walls are _thin_. In an N-frame six-shot design, the recesses for the cylinder stop are right over the chamber. A smaller-frame five-shot (such as the Taurus or an L frame S&W) would have walls much thicker and the the locking recesses are in the thick web between the chambers.
The extraction issues with the small rim in DA revolvers have been covered by others here. PistolPete has more experience carrying the 25-5 than I have. (We've also argued the hot load issue a number of times.

)
Ruger may make a Super Redhawk in .45C now; I don't know. It would hardly qualify as a carry piece though.
While I did use a Ruger Blackhawk .45C as a car gun for a while, SA revolvers usually aren't considered for carry nowadays.
The monster single-actions from Ruger and Freedom have engineering design, metalurgy and heat treat suitable for 40-50,000 PSI. I have no quarrel with hotrodding these. Extraction is a non-issue with a SA.
BTW, the original blackpowder loads were fairly hot; close to 1000fps with a 40 grain charge. With modern solid-head brass I could only get about 35 grains of 3F in it. Still an excellent hunting load, and with Keith SWC bullets the extra 11% of frontal area is significant I think.
I guess it comes down to what your personal comfort level in reloading is. My philosophy has always been, if you need more power, get a more powerful cartridge. The exceptions were where (in HiPower competition) the caliber was mandated so one had to squeeze every last FPS out of the case.
Regards,
Pat