Living in the frozen North as I do, and being close to sources within certain LEA's up here; I am given to understand the Speer GDHP 180 gr is king of the hill in felony felon-stops (excuse the redundancy) on BG's who need to be stopped. Through car windshields, side door glass, 4 layers of denim and 2 layers of leather, what have you, the GDHP penetrates and delivers. To the morgue.
I do not endorse any particular brand of ammunition. I believe Winchester's RA40T is as good as the 180 GDHP, but since our boys in MKE are using the Speer loading and it's working that's what I'd stick with.
Just my dos centavos.