Hello. My "house 45" is currently loaded with Winchester 230-gr. LE ammo. The reason is that the load has proven accurate reliable and POA matches POI in this fixed sight automatic. Also, this load reportedly does well in actual shooting scenarios.
The 185-gr. DPX +P is a relatively new load but one that does seem to be a most viable defense load for those wanting a faster velocity but still with the 45-caliber diameter, combined with a new technology homogeneous bullet that seems destined to both expand and penetrate sufficiently regardless of the barrier. The dreaded 4-layers of denim barrier before smacking 10% gelatin is no problem for either round and this seems to be the one most defense shooters look to.
Either of these loads should be at or near the top of the list for "effective loads" in this caliber. I would not be afraid to use either one for serious purposes, assuming that my gun/magazines had previously proven reliable with whichever was selected.
I am not sure if you've seen it or not but if not, here's an informal look at Corbon's DPX in .45 ACP:
http://www.hipowersandhandguns.com/Corbon%20.45%20ACP.htm
Best.