It depends on the mission, the weapon and the personal skill of the operator.
For a G.P. load (hunting and defense) I have to say I would go along with Steve's preference of a 200 at about 1000 fps, unless it was really big stuff we were hunting (not likely I would choose the .44 spl for that though).
For strictly defense and with a lighter more concealable firearm (like one of the Taurus snubs or a Charter arms) I might be tempted to try a lighter bullet. When I did carry the Charter as a backup back in the 70s I loaded 200 gr. Speer bullets to about 900 fps but there weren't any 165s or factory loads that compared. Today for the light guns I might experiment with the light bullets.
Still my gut tells me to go medium weight at about 1,000 fps.
Onward,
Jim